Principal Investigator

Paul Hudson

2009 PhD Chemical Engineering, University of California, Berkeley USA
2004 BSc Chemical Engineering, North Carolina State University USA

In 2013 I helped to start research on cyanobacteria at KTH, on a project to produce butanol. That project evolved into this group. In 2014 I became a SciLifeLab Fellow, and moved to Science for Life Laboratory. As group leader, I direct our ongoing projects so that they complement one another. As an advisor, I want students to learn to look for how research projects fit together. I also want for students to develop technical skills in instrumentation and data processing. It is their success in this that has allowed our research to expand into new areas.

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Michael Jahn

2015 PhD Environmental Microbiology, Helmholtz-Centre for Environmental Research Leipzig Germany
2011 BSc Biology, University Dresden Germany

My primary field of interest is microbial biotechnology, in the widest sense. I like to work at the interphase of experimental and computational biology. I am an enthusiastic user of R statistical programming, but also use python for metabolic modeling. I support openness and transparency in science. A decent summary of the software packages and models that I (co)-develop are on my homepage. I work on different projects evolving around microbial systems biology.

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Ivana Cengic

2019 PhD Biotechnology, KTH Sweden
2013 MSc Industrial and Environmental Biotechnology, KTH Sweden

My main scientific interest is the fatty acid biosynthesis pathway in cyanobacteria. I study the transcriptional regulation of this pathway in different cyanobacteria, and whether this knowledge could be useful for metabolic engineering. Another aspect of my work is building synthetic biology tools to promote cyanobacteria as a viable cell factory. I developed an inducible CRISPRi-system, as well as a strategy for display of small affinity proteins on the cell surface. I am currently working on a tightly regulated CRISPR-system for inducible and efficient genome editing, and a metabolite biosensor that could be used in high-throughput screening of cyanobacteria libraries.

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Nick Crang

2019 DPhil Interdisciplinary Bioscience, University of Oxford UK
2015 Bachelors degree in Genetics, University of York UK

My Ph.D. work was on the metabolism of the N2 fixing rhizobia. I joined the lab in 2020 and my work is focused on using screening libraries to investigate chemolithoautotrophs with industrial potential. I approach science with more of an engineering mindset i.e. what can I do with this information? Because of this I really appreciate how the research focus of our group manages to combine together both applied and fundamental research. My skillset is primarily wet lab focused, with particular specialties in cloning and mutagenesis.

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Rui Miao

2018 PhD Microbial Chemistry, Uppsala University Sweden
2010 BSc Biotechnology and BA Law, Tianjin Normal University China

I have been a good friend of cyanobacteria for many years. I have done research on metabolic engineering and protein engineering in a model unicellular cyanobacteria strain. I also have a great interest, and have been doing deep investigations on, the physiological effects of carbon-based end metabolites in cyanobacteria. My current research is aiming for discovering and engineering good bacterial candidates for efficient CO2 fixation and chemical production. From 2019 to 2020 I was a Post-doc researcher in French Alternative Energies and Atomic Energy Commission, CEA Cadarache.

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Elias Englund

2017 PhD Microbial Chemistry, Uppsala University Sweden

I did my PhD in Uppsala University doing metabolic engineering on cyanobacteria for terpenoid production. After that I was a Post-doc researcher at the Joint Bioenergy Institute in Berkeley USA from 2018-2021 working on high throughput polyketide synthase engineering. In the fall of 2021, I joined the Hudson lab. Here I will continue my research interest of applying modern methods for metabolic engineering by developing and applying methods for high throughput engineering of cyanobacteria.

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Ute Hoffmann

2021 PhD Biology, University Freiburg Germany
2017 MSc Biochemistry & Biophysics, University Freiburg Germany
2013 BSc Biology, University Freiburg Germany

During my PhD I tried to unravel the secrets of a central ribonuclease in the cyanobacterium Synechocystis sp. PCC 6803. To do so, I combined both experimental wet lab work and bioinformatic analyses. I am enthusiastic to now use this knowledge to change gear towards more applied research on cyanobacteria and help to investigate the potential use of cyanobacteria and their enzymes to create more sustainable solutions.

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Grad Students

Markus Janasch

2015 MSc Biotechnology, Chalmers University of Technology Sweden
2013 BSc Biosystems Engineering, Otto-von-Guericke-Universität Magdeburg, Germany

My scientific interests lie in combining systems biology and metabolic engineering, with special focus on modifying photosynthetic microbes for a more sustainable economy. I feel most enthusiastic about how thermodynamic and enzyme kinetic constraints shape the resource allocation of carbon fixation metabolism. I like the combination of experimental omics datasets and computational models to identify regulatory structures and targets for metabolic engineering.

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Jan Karlsen

2016 MSc Industrial and Environmental Biotechnology, KTH Sweden
2013 BSc Environmental Engineering, Lund University Sweden

My general research interests are within ecology, biology, technology and environmental preservation. During my undergraduate studies, I became fascinated by the idea to make fuels from microalgae and cyanobacteria, so I was happy to find a position as a PhD student in the Hudson lab in 2016. My current research tries to support engineering efforts in cyanobacteria by investigating gene and metabolic regulation using a systems biology approach and a combination of high-throughput techniques such as mRNA-seq, ribo-seq, and quantitative proteomics. I am fond of wet-lab work and particularly cell cultivation technology.

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Emil Sporre

2020 MSc Medical Biotechnology, KTH Sweden

I joined the group during the Spring of 2020 for my MSc thesis degree project. After graduation, I stayed with the group to keep working on the project – interaction proteomics in autotrophic bacteria. The focus of the project is to explore post-translational regulation of carbon fixation in multiple bacteria to enable a future increase in carbon flux through the cycle. I am also eager and curious to explore other topics, and develop both wet and dry lab skills.

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Anna Karlsson

2021 MSc Industrial Biotechnology, KTH Sweden

I joined the lab in 2021. I am interested in metabolism in all of its varieties. In my master's thesis at KTH I studied the puzzle of amino acid secretion by anaerobic Clostridia. In this group I will work to develop and apply new proteomics methods for cyanobacteria and plant. Our hope is to uncover new types of regulation in carbon fixation. Alteration of these regulations could lead to cells with faster carbon uptake or altered product secretion.

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Synechocystis strain PCC 6803

Evolved billions of years ago

I was isolated for research around 1970 from a lake near Berkeley, California. I was the first photosynthetic organism to have a genome sequenced. My main interests are light and CO2. I exist in thousands of tubes and flasks around the world. Through this distributed existence I silently and relentlessly sample genetic mutation. In some of my many permutations, I can consume glucose. In others I move toward the light, in others still I retract from it. I joined this group in 2011, was discarded after a contamination was discovered, but returned again in 2012.

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  • Johannes Asplund-Samuelsson, Data Scientist, Scania
  • Arvid Gynnå, Polisen
  • Sara Baldanta, Ph.D. student University Complutense, Madrid
  • Kiyan Shabestary, Postdoc Imperial College London
  • Cristopher Ollagnier Widen
  • Manuel Bruch, Ph.D. student, University College Dublin
  • Lun Yao, Associate Professor, Dailan Institute of Chemical Physics
  • Kyle Kimler, Associate computational scientist, Broad Institute USA
  • Olivia Hallman, Laboratory engineer, GE Healthcare Sweden
  • Johann Bauerfeind, Founder and CEO, Solaga Germany
  • Da Wang
  • Emil Ljungqvist, Ph.D. student, KTH Sweden
  • Astrid Nilsson, Research associate, Swedish Environmental Institute
  • Raquel Perucca, Ph.D. student, Lund Sweden
  • Vital Vialas, Data Scientist, Airmee Sweden
  • Dora Vitay, Ph.D. student, Copenhagen Denmark
  • Linnea Österberg, Ph.D. student, Chalmers Sweden
  • Quentin Thomas, Ph.D. student, Copenhagen Denmark
  • Danuta Kaczmarzyk, Scientist, Photanol Netherlands
  • Petter Hammar, Scientist, Astrego Therapeutics Sweden
  • Josefine Anfelt, Scientist, Cytiva Sweden
  • Susan Bigesse, Process engineer, Rentschler Biopharma Germany
  • Josefin van der Meer, Process engineer, Cortus Energy Sweden
  • Mahanand Muppidi
  • Anja Erhmann, Ph.D. student, Copenhagen Denmark
  • Heriberto Velez, Researcher, Sweden Agricultural University
  • Amanda Särnegrim, Product development, Aerosol Scandinavia

Find Us

We are located at Science for Life Laboratory, a “satellite” campus of KTH Royal Institute of Technology.

Visiting address: Tomtebodavägen 23B, 17121 Solna, Sweden. Bus stop “Karolinska Institutet Biomedicum,” Bus lines 3, 6. Nearest subway stop is St. Eriksplan (20 minutes walk).